Scoping review: surface proteins on synovial fibroblasts and macrophages of patients with osteoarthritis
Osteoarthritis (OA) is the most common joint disease in the world. It is
characterised by degradative and reparative processes of the articular cartilage and the subchondral bone. To date, there is no causal treatment available for this disease, partly due to the fact that the pathophysiological mechanisms of OA are still not fully understood. Fibroblasts, which play an important role in the production of extracellular matrix (ECM) and synovial fluid, are the most abundant cell type in the synovium. Furthermore, macrophages are the most prominent immune cells in the synovium. The role of these cells in the pathogenesis of OA seems to be promising and therefore further research is recommended. The aim of this scoping review is to summarise the existing literature concerning surface proteins on synovial fibroblasts and macrophages in patients with osteoarthritis to determine their role in the pathogenesis of OA.
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