Mondproblemen bij oncologische patiënten, behandeld met chemotherapie

Nele Tjampens
Mondproblemen veroorzaakt door chemotherapie is een complicatie dat veel voorkomt. Door inzicht te krijgen in het ontstaan van deze mondproblemen kan er sneller ingespeeld worden op de optredende mondproblemen en kunnen deze sneller behandeld worden. Hierdoor zal de patiënt minder nevenwerkingen ondervinden.

Mondproblemen bij oncologische patiënten, behandeld met chemotherapie

PROBLEEMSTELLING MET ONDERZOEKSVRAAG:

Mondproblemen bij oncologische patiënten behandeld met chemotherapie zijn een vaak voorkomend probleem. Hierdoor ervaart de patiënt veel problemen op verschillende vlakken waardoor er een verminderde levenskwaliteit ervaren wordt. Het uitvoeren van een goede mondzorg is hierbij essentieel.
Hierdoor werd een onderzoeksvraag geformuleerd: op welke manier ontstaan mondproblemen bij oncologische patiënten die behandeld worden met chemotherapie, welke preventieve maatregelen kunnen er toegepast worden zodat de kans op het ontstaan ervan kleiner wordt en welke behandelingsmethodes kunnen toegepast worden zodat de nadelige symptomen beperkt worden?’

METHODOLOGIE:

Er werd gebruik gemaakt van een kwalitatief onderzoek. Het doel van de vragenlijst was om de kennis van de verpleegkundigen na te gaan omtrent mondzorg bij oncologische patiënten. Er werden veertien vragenlijsten ingevuld door de verpleegkundigen. 
 

RESULTAAT:

Er blijkt een kennistekort aanwezig te zijn bij de verpleegkundigen omtrent de mogelijke mondproblemen veroorzaakt door chemotherapie. Daarnaast is er ook een kennistekort omtrent het correct uitvoeren van de mondzorg.   

BESLUIT:

Het is aangewezen dat de kennis van de verpleegkundigen verruimd wordt. Hierdoor kan de mondzorg beter uitgevoerd worden en zal er een betere mondinspectie plaatsvinden. Dit zal resulteren in een vroege detectie van mondproblemen waardoor er sneller een behandeling kan gestart worden.
 

Bibliografie

Arruda, C.N.F., Sorgini, D.B., Oliveira, V.D.C., Macedo, A.P., Lovato, C.H.S & Paranhos, H.D.F.O. (2015). Effect of denture cleansers on heat-polymerized acrylic resin: a five-year-simulated period of use. Brazilian dental journal, 26, nr. 4, pp. 404-408.

Baba, Y., Sato, Y., Owada, G. & Minakuchi, S. (2018). Effectiveness of a combination denture-cleaning method versus a mechanical method: comparison of denture cleanliness, patient satisfaction and oral health-related quality of life. Journal of prosthodontic research, 10, nr. 5, pp. 1-5.

Basman, A., Peker, I., Akca, G., Alkurt, M.T., Sarikir, C. & Celik, I. (2016). Evaluation of toothbrush disinfection via different methods. Brazilian oral research, 30, nr. 1, pp. 1-6.

Boltong, A., Aranda, S., Keast, R., Wynne, R., Francis, P.A., Chirgwin, J. & Gough, K. (2014). A Prospective Cohort Study of the Effects of Adjuvant Breast Cancer Chemotherapy on Taste Function, Food Liking, Appetite and Associated Nutritional Outcomes. PLOS ONE, 9, nr. 7, pp. 1-9. 

Botelho, J.N., Del Bel Cury, A.A., Silva, W.J.D., Tenuta, L.M.A. & Cury, J.A. (2014). The effect of fluoride toothpaste on root dentine demineralization progression: a pilot study. Brazilian oral research, 1, nr. 28, pp. 1-5.

Buglione, M., Cavagnini, R., Di Rosario, F., Maddalo, M., Vassalli, L., Grisanti, S., Salgarello, S., Orlandi, E., Bossi, P., Majorana, A., Gastaldi, G., Berruti, A., Trippa, F., Nicolai, P., Barasch, A., Russi, E.G., Durlacher, J.R., Murphy, B. & Magrini, S.M. (2016). Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: Xerostomia and trismus (Part 2). Literature review and consensus statement. Critical Reviews in Oncology/Hematology, 102, pp. 47-54.

Chandel, S., Khan, M.A., Singh, N., Agrawal, A. & Khare, V. (2017). The effect of sodium bicarbonate oral rinse on salivary pH and oral microflora: A prospective cohort study. National Journal of Maxillofacial Surgery, 8, nr. 2, pp. 106-109.

Chattopadhyay, S., Saha, A., Azam, M., Mukherjee, A. & Sur, P.K. (2014). Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: A prospective randomized study. South Asian Journal of Cancer, 3, nr. 1, pp. 8-12.

Chaundhry, S. & Khan, A.A. (2018). Ensuring quality of life of cancer patients through optimal oral health. Journal of Cancer & Allied Specialties, 3, nr. 5, pp. 1.

Coolbrandt, A., Decoene, E., De Munter, J., Devroede, N., Jonckers, S., Vandamme, K. & Van de Velde, V. (2015). Orale mucositis. Landelijke richtlijn, 2, nr. 3, pp. 1-75.

Declerck, D. (2010). Mondzorg voor, tijdens en na chemotherapie. In De Baat, C., Allard, R.H.B., Aps, J.K.M., Duyck, J., Fokkema, S.J., Jacobs, R. & Vissink, A. (Red.), Het tandheelkundig jaar 2010, pp. 78-89. Houten: Bohn Stafleu van Loghum.

D’haese, S. (2016). Basisboek oncologie voor verpleegkundigen. (3de dr.). Berchem: De Boeck.

Eduardo, F.D.P., Bezinelli, L.M., Carvalho, D.L.C., Lopes, R.M.D.G., Fernandes, J.F., Brumatti, M., Vince, C.S.C., Azambuja, A.M.P. & Correa, L. (2015). Oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation: Clinical outcomes in a context of specialized oral care using low-level laser therapy. Pediatric transplantation, 19, nr. 3, pp. 316-325.

Erdem, Ö. & Güngörmüs, Z. (2014). The effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy. Holistic nursing practice, 28, nr. 4, pp. 242-246.

Ferruzzi, F., Martins, J.C., Mori, A.A., Santin, G.C., Kurihara, E. & Sabio, S. (2015). Influence of educational materials on the hygiene and utilization habits of denture wearers. Gen Dent, 63, nr. 4, pp. 6-10.

Gottlieb, R.M. (2017). Brushes useful for cleaning teeth and interdental spaces. United States patent application, 4, nr. 14, pp. 1-13.

Gupta, R., Aggarwal, R. & Aeran, H. (2016). Comparison of various methods of disinfecting acrylic dentures: Assessement of antimicrobial efficacy & dimensional changes. International Journal of Oral Health Dentistry, 2, nr. 3, pp. 143-147.

Haddadi, M., Hashemifard, H.R., Ganjloo, J. & Tabarraie, Y. (2016). The Effect of Sucking Bits of Ice Containing (mentha) Mint Extract on Xerostomia, During Chemotherapy in Patients with Breast Cancer. Journal of Biomedicine and Health, 1, nr. 4, pp. 1-3.

Harding, J. (2017). Dental care of cancer patients before, during and after treatment. BDJ Team, 4, nr. 1, pp. 10-12. 

Hogeveen, E. (2016). Essentials voor de preventieassistent. Standby, 30, nr. 1, pp. 23-23.

Hong, C.H., Hu, S., Haverman, T., Stokman, M., Napeňas,J.J., Bos-den Braber, J., Gerber, E., Geuke, M., Vardas, E., Waltimo, T., Jensen, S.B. & Saunders, D.P. (2018). A systematic review of dental disease management in cancer patients. Supportive Care in Cancer, 26, nr. 1, pp. 155-174.   

Idahosa, C.N. & Kerr, A.R. (2017). Clinical Evaluation of Oral Diseases. Contemporary Oral Medicine, 1, pp. 1-35.

IJpma, I., Timmermans, E.R., Renken, R.J., Ter Horst, G.J. & Reyners, A.K. (2017). Metallic Taste in Cancer Patients Treated with Systemic Therapy: A Questionnaire-based Study. Nutrition and cancer, 69, nr. 1, pp. 140-145.

Jensen, S.B., Jarvis, V., Zadik, Y., Barasch, A., Ariyawardana, A., Hovan, A., Yarom, N., Lalla, R.V., Bowen, J. & Elad, S. (2013). Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients. Supportive Care in Cancer, 21, nr. 11, pp. 3223-3232.

Johnson, T.M., Worthington, H.V., Clarkson, J.E., Pokepovic, P.T., Sambunjak, D. & Imai, P. (2015). Mechanical interdental cleaning for preventing and controlling periodontal diseases and dental caries. The Cochrane Library, 12, nr. 10, pp. 1-17.

Kammers, A.C.E., Zanetti, A.L., Lacerda, T.E.S.P., Aroca, J.P., Camilotti, V. & Mendonça, M.J. (2015). Toothbrush handles individually adapted for use by elderly patients to reduce biofilm on complete dentures: a pilot study. Journal of clinical and diagnostic research: JCDR, 9, nr. 5, pp. 94-97.

Khalili, Z. (2016). Comparison of the effect of microwave radiation in the disinfection complete dentures contaminated with two types of bacteria S. aureus and P. aeruginosa (in vitro) with mechanical methods and chemical solutions of glutaraldehyde. International journal of advanced biothecnology and research, 7, nr. 3, pp. 2017-2025.

Kiesow, A., Sarembe, S., Pizzey, R.L., Axe, A.S. & Bradshaw, D.J. (2016). Material compatibility and antimicrobial activity of consumer products commonly used to clean dentures. Journal of Prosthetic Dentistry, 115, nr. 2, pp. 189-198.

Köstler, W.J., Hejna, M., Wenzel, C. & Zielinski, C.C. (2001). Oral mucositis complicating chemotherapy and/or radiotherapy: options for prevention and treatment. CA: a cancer journal for clinicians, 51, nr. 5, pp. 290-315.

Kripa, A.A. (2017). Systematic Review on Interventions for Mucositis in Cancer Therapy – An Update. International Journal of Oncological Nursing, 2, nr. 1, pp. 15-22.

Kulkarni, P., Singh, D.K. & Jalaluddin, M. (2017). Comparison of efficacy of manual and powered toothbrushes in plaque control and gingival inflammation: A clinical study among the population of East Indian region. Journal of International Society of Preventive & Community Dentistry, 7, nr. 4, pp. 168.

Laleman, I., Koop, R., Teughels, W., Dekeyser, C. & Quirynen, M. (2018). Influence of tongue brushing and scraping on the oral microflora of periodontitis patients. Journal of periodontal research, 53, nr. 1, pp. 73-79.

Lalla, R.V., Saunders, D.P. & Peterson, D.E. (2014). Chemotherapy or radiation-induced oral mucositis. Dental Clinics, 58, nr. 2, pp. 341-349.

Loudon, H. (2016). Patient support during cytotoxic chemotherapy – a practical summary for nursing staff: oncology nursing. Professional Nursing Today, 20, nr. 2, pp. 4-6.

Luz, M., Klingbeil, M.F.G., Henriques, P. & Lewgoy, H.R. (2016). Comparison between Interdental Brush and Dental Floss for Controlling Interproximal Biofilm in Teeth and Implants. Dent Health Curr Res, 2, nr. 3, pp. 1-4.

Maart, R., Grobler, S.R., Kruijsse, H.W., Osman, Y., Patel, N. & Moodley, D. (2016). The whitening effect of four different commercial denture cleansers on stained acrylic resin. South African Dental Journal, 71, nr. 3, pp. 106-111.

Martini, F. & Bartholomew, E. (2016). Anatomie en fysiologie: een inleiding. (2de dr.). Amsterdam: Pearson.

Mercadante, S., Aielli, F., Adile, C., Ferrera, P., Valle, A., Fusco, F., Caruselli, A., Cartoni, C., Massimo, P., Masedu, F.v Valenti, M. & Porzio, G. (2015). Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients. Supportive Care in Cancer, 23, nr. 11, pp. 3249-3255. 

Milanesi, F.C., Kauer, B., Wagner, T.P., Daudt, L.D. & Haas, A.N. (2016). Self-reported halitosis and associated demographic and behavioral factors. Brazilian oral research, 30, nr. 1, pp. 1-8.

Mojarad, N., Khalili, Z. & Aalaei, S. (2017). A comparison of the efficacy of mechanical, chemical and microwave radiation methods in disinfecting complete dentures. Dental research journal, 14, nr. 2, pp. 131.

Nazzal, H., Duggal, M.S., Kowash, M.B., Kang, J. & Toumba, K.J. (2016). Comparison of residual salivary fluoride retention using amine fluoride toothpastes in caries-free and carie-prone children. European Archives of Paediatric Dentistry, 17, nr. 3, pp. 165-169.

Nesher, L. & Rolston, K.V. (2014). The current spectrum of infection in cancer patients with chemotherapy related neutropenia. Infection, 42, nr. 1, pp. 5-13.

Papadiochou, S. & Polyzois, G. (2017). Hygiene practices in removable prosthodontics: A systematic review. International journal of dental hygiene, 10, nr. 11, pp. 1-23.

Paul, B., Basu, M., Dutta, S., Chattopadhyay, S., Sinha, D. & Misra, R. (2014). Awareness and practices of oral hygiene and its relation to sociodemographic factors among patients attending the general outpatient department in a tertiary care hospital of Kolkata, India. Journal of family medicine and primary care, 3, nr. 2, pp. 107 – 111.

Peterson, D.E., Boers-Doets, C.B., Bensadoun, R.J. & Herrstedt, J. (2015). Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelinesfor diagnosis, treatment, and follow-up. Annals of Oncology, 26, nr. 5, pp. 139-151.

Peterson, D.E., Öhrn, K., Bowen, J., Fliedner, M., Lees, J., Loprinzi, C., Mori, T., Osaguona, A., Weike, D.S., Elad, S. & Lalla, R.V. (2013). Systematic review or oral cryotherapy for management of oral mucositis caused by cancer therapy. Supportive Care in Cancer, 21, nr. 1, pp. 327-332.

Pires, C.W., Fraga, S., Beck, A.C., Braun, K.O. & Peres, P.E. (2017). Chemical methods for cleaning conventional dentures: what is the best antimicrobial option? An in vitro study. Oral health & preventive dentistry, 15, nr. 1, pp. 1-5.

Poulopoulos, A., Papadopoulos, P. & Andreadis, P. (2017). Chemotherapy: oral side effects and dental interventions. A review of the literature. Stomatological Disease and Science, 1, pp. 35-49.  

Rapone, B., Nardi, G.M., Di Venere, D., Pettini, F., Grassi, F.R. & Corsalini, M. (2016). Oral hygiene in patients with oral cancer undergoing chemotherapy and/or radiotherapy after prosthesis rehabilitation: protocol proposal. ORAL & implantology, 9, pp. 90-97.

Riley, P., McCabe, M.G. & Glenny, A.M. (2016). Oral cryotherapy for preventing oral mucositis in patients receiving cancer treatment. JAMA Oncology Clinical Evidence Synopsis, 2, nr. 10, pp. 1365-1366. 

Rosema, M. (2015). The battle of the brushes. Tandartspraktijk, 36, nr. 5, pp. 35-37.

Sayles, C., Hickerson, S.C., Bhat, R.R., Hall, J., Garey, K.W. & Trivedi, M.V. (2016). Oral glutamine in preventing treatment – related mucositis in adult patients with cancer: a systematic review. Nutrition in Clinical Practice, 31, nr. 2, pp. 171-179.

Scheibler, E., Garcia, M.C.R., Medina da Silva, R., Figueiredo, M.A., Salum, F.G. & Cherubini, K. (2017). Use of nystatin and chlorhexidine in oral medicine: Properties, indications and pitfalls with focus on geriatric patients. Gerodontology, 34, nr. 3, pp. 291-298.

Silva, F.C., Marto, J.M., Salgado, A., Machado, P., Silva, A.N. & Almeida, A.J. (2017). Nystatin and lidocaine pastilles for the local treatment of oral mucositis. Pharmaceutical development and technology, 22, nr. 2, pp. 266-274.

Stokman, M.A. & Spijkervet, F.K.L. (2009). Behandeling van mucositis. In De Baat, C., Allard, R.H.B., Aps, J.K.M., Duyck, J., Fokkema, S.J., Jacobs, R. & Vissink, A. (Red.), Het tandheelkundig jaar 2009, pp. 55-66. Houten: Bohn Stafleu van Loghum.

Stokman, M.A., Vissink, A. & Spijkervet, F.K.L. (2008). Focusonderzoek en mondverzorging bij patiënten met kanker. Nederlands Tijdschrift voor Tandheelkunde, 115, nr. 4, pp. 203-210.

Tipian, C. (2014). Brushing up on mouth care for cancer patients with mucositis. American nurse today, 9, nr. 11, pp. 38-40.

Van den Beuken – van Everdingen, M.H.J. & Janssen-Jongen, M.L.E. (2010). Mondproblemen. In Janssen-Jongen, M.L.E. (Red.), het palliatief formularium, pp. 110-121. Houten: Bohn Stafleu van Loghum.

Vanlancker, E. (2013). Invloed van orale microbiota op epitheliale wondheling bij orale mucositis (masterproef). Universiteit Gent, Faculteit Bio-ingenieurswetenschappen.

Verstraeten, M. (2016). Mondproblemen door chemo of bestraling. Nursing, 22, nr. 5, pp. 34-37.

Wodzinski, A. (2016). Potential Benefits of Oral Cryotherapy for Chemotherapy-Induced Mucositis. Clinical journal of oncology nursing, 20, nr. 5, pp. 462-465.

Wong, H.M. (2014). Oral complications and management strategies for patients undergoing cancer therapy. The scientific World Journal, 2014, pp. 1-14.

Universiteit of Hogeschool
Brugopleiding verpleegkunde
Publicatiejaar
2018
Promotor(en)
Dhr. Kemps
Kernwoorden
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