FIP: ‘Een dodelijke ziekte bij katten die enkel kan worden behandeld met een illegaal medicijn dat ook nog eens stukken van mensen kost’.
Feliene infectieuze peritonitis is een ziekte die voorkomt bij katten die zonder adequate behandeling in alle gevallen een fatale afloop kent. De ziekte wordt veroorzaakt door een coronavirus die tot dezelfde familie behoort als het humane coronavirus, maar niet tot hetzelfde genus. Dit betekent dat dit virus niet kan worden overgebracht van de besmette kat naar de mens.
FIP kan voorkomen bij alle leeftijden, maar wordt voornamelijk gezien bij jonge katten die een periode van stress hebben gekend. Katten die deze ziekte hebben ontwikkeld zijn lusteloos, raken hun eetlust kwijt, maken in veel gevallen koorts en/of krijgen een dikke buik. Daarnaast kunnen ook vele andere klachten zich voordoen zoals problemen met de ogen of hersenen. Deze verscheidenheid aan klachten maakt het stellen van de diagnose soms erg moeilijk. Een bloedonderzoek en onder andere een echo van de buik waarbij buikvocht kan worden aangeprikt kan hierbij helpen.
Tot een aantal jaren geleden was er geen zicht op een curatieve therapie waardoor deze ziekte bij iedere kat fataal afliep. Gelukkig heeft de wetenschap niet stilgestaan en blijkt er toch een oplossing voorhanden te zijn in de vorm van een molecule met de naam GS-441524. Echter is het gebruik van medicatie met deze molecule nog niet toegestaan in Europa, dus ook niet in België en Nederland. Dit leidt tot grote frustratie bij op de eerste plaats de eigenaars en op de tweede plaats de dierenartsen. Beide partijen staan met de rug tegen de muur want zonder deze medicatie sterven hun geliefde viervoeters een vreselijke dood. Sommige eigenaars laten zich niet tegenhouden door de wetgeving en kopen de medicatie op de zwarte markt. Een behandeling bestaat uit dagelijkse injecties gedurende 84 dagen die de eigenaars zelf moeten toedienen. Hierbij kunnen ze geen hulp krijgen van hun dierenarts want zij dreigen dan hun licentie te verliezen. De eigenaars zijn dus op zichzelf en hun lotgenoten aangewezen. Naast deze intensieve behandeling en emotionele rollercoaster kost de behandeling ook nog enkele duizenden euro’s, wat dus een financiële strop is voor vele baasjes.
Het bedrijf dat dit medicijn in handen heeft weigert het te laten registreren voor katten omdat het de registratie voor humaan gebruik bij coronapatiënten zou kunnen belemmeren. Een geldkwestie dus…
Vanwege de oneerlijke strijd tegen deze ziekte en de grote farmaceutische industrie ben ik gegevens gaan verzamelen van katten die werden behandeld met dit medicijn. Ik heb duidelijk in kaart kunnen brengen wat het effect is van dit medicijn bij katten die gediagnosticeerd werden met FIP. In alle gevallen zijn de katten genezen en doen het tot op heden erg goed. Onderstaande figuur laat het herstel zien van één van de patiënten die behandeld is met het GS-441524. Ik hoop dan ook dat mijn masterthesis kan bijdragen aan de legalisering van deze medicatie. Het uitblijven van de legalisering heeft immers al onnodig veel katten het leven gekost. Er is een behandeling en het wordt hoog tijd dat die gebruikt mag gaan worden.
Bibliografie
Addie, D.D., Curran, S., Bellini, F., Crowe, B., Sheehan, E., Ukrainchuk, L., Decaro, N., 2020. Oral Mutian®Xstopped faecal feline coronavirus shedding by naturally infected cats. Research in Veterinary Science 130, 222-229.
Addie, D.D., Houe, L., Maitland, K., Passantino, G., Decaro, N., 2020. Effect of cat litters on feline coronavirus infection of cell culture and cats. Journal of Feline Medicine and Surgery 22(4), 350-357.
Addie, D.D., le Poder, S., Burr, P., Decaro, N., Graham, E., Hofmann-Lehmann, R., Jarrett, O., McDonald, M., Meli, M.L., 2015. Utility of feline coronavirus antibody tests. Journal of Feline Medicine and Surgery (2), 152-62.
Addie, D.D., Paltrinieri, S., Pedersen, N.C., 2004. Seconginternational feline coronavirus/feline infectious peritonitis symposium. Recommendations from workshops of the second international feline coronavirus/feline infectious peritonitis symposium. Journal of Feline Medicine and Surgery 6(2), 125-30.
Addie, D.D., Belák, S., Boucraut-Baralon, C., Egberink, H., Frymus, T., Gruffydd-Jones, T., Hartmann, K., Hosie, M.J., Lloret, A., Lutz, H., et al., 2021. Feline infectious peritonitis. ABCD guidelines on prevention and management. Journal of Feline Medicine and Surgery 11(7),594-604.
Addie, D.D., Jarrett, O., 2001. Use of a reverse-transcriptase polymerase chain reaction for monitoring the shedding of feline coronavirus by healthy cats. Veterinary Record 148(21), 649-53.
Addie, D.D., Schaap, I.A.T., Nicolson, L., Jarrett, O., 2003. Persistence and transmission of natural type I feline coronavirus infection. Journal of General Virology 84, 2735-2744.
Ahola, M.K., Vapalahti, K., Lohi, H., 2017. Early weaning increases aggression and stereotypic behaviour in cats. Scientific Reports September 4,7(1), 10412.
Amirian, E.S., Levy, J.K., 2020. Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic option for coronaviruses. One Health 9, 100128.
Baric, R.S., Nelson, G.W., Fleming, J.O., Deans, R.J., Keck, J.G., Casteel, N., Stohlman, S.A., 1988. Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription. Journal of Virology 62(11),4280-7.
Barker, E.N., Tasker, S., Gruffydd-Jones, T.J., Tuplin, C.K., Burton, K., Porter, E., Day, M.J., Harley, R., Fews, D., Helps, C.R., et al., 2013. Phylogenetic analysis of feline coronavirus strains in an epizootic outbreak of feline infectious peritonitis. Journal of Veterinary Internal Medicine 27(3), 445-50.
Beigel, J.H., Tomashek, K.M., Dodd, L.E., Mehta, A.K., Zingman, B.S., Kalil, A.C., Hohmann, E., Chu, H.Y., Luetkemeyer, A., Kline, S., et al., 2020. Remdesivir for the Treatment of Covid-19 - Final Report. The new England Journal of Medicine 383(19), 1813-1826.
Capozza, P., Pratelli, A., Camero, M., Lanave, G., Greco, G., Pellegrini, F., Tempesta, M., 2021. Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms. Animals 11, 3548.
Cave, T.A., Golder, M.C., Simpson, J., Addie, D.D., 2004. Risk factors for feline coronavirus seropositivity in cats relinquished to a UK rescue charity. Journal of Feline Medical Surgery 6(2), 53–58.
Ceciliani, F., Grossi, C., Giordano, A., Pocacqua, V., Paltrinieri, S., 2004. Decreased sialylation of the acute phase protein α1-acid glycoprotein in feline infectious peritonitis (FIP). Veterinary Immunology and Immunopathology 99, 229–236.
Corapi, W.V., Darteil, R.J., Audonnet, J.C., Chappuis, G.E., 1995. Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement. Journal of Virology 69, 2858-2862.
Cornelissen, E., Dewerchin, H.L., Van Hamme, E., Nauwynck, H.J., 2007. Absence of surface expression of feline infectious peritonitis virus (FIPV) antigens on infected cells isolated from cats with FIP. Veterinary Microbioly 121(1-2), 131-7.
Chang, H.W., Egberink, H.F., Halpin, R., Spiro, D.J., Rottier, P.J., 2012. Spike protein fusion peptide and feline coronavirus virulence. Emerging Infectious Diseases 7, 1089-95.
Channappanavar, R., Zhao, J., Perlman, S., 2014. T cell-mediated immune response to respiratory coronaviruses. Immunologic Research 59(1-3), 118-28.
de Groot-Mijnes, J.D., van Dun, J.M., van der Most, R.G., de Groot, R.J., 2005. Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease. Journal of Virology 79(2), 1036-44.
Dhabhar, F.S., 2009. Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology. Neuroimmunomodulation 16(5), 300-17.
Dedeurwaerder, A., Desmarets, L.M., Olyslaegers, D.A.J., Vermeulen, B.L., Dewerchin, H.L., Nauwynck, H.J. 2013. The role of accessory proteins in the replication of feline infectious peritonitis virus in peripheral blood monocytes. Veterinary Microbiology 162(2-4), 447-455.
Delaplace, M., Huet, H., Gambino, A., Le Poder, S., 2021. Feline Coronavirus Antivirals: A Review. Pathogens 10(9), 1150.
Desmarets, L.M., Vermeulen, B.L., Theuns, S., Conceição-Neto, N., Zeller, M., Roukaerts, I.D., Acar, D.D., Olyslaegers, D.A., Van Ranst, M., Matthijnssens, J., Nauwynck, H.J., 2016. Experimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures. Scientific reports 6; 20022.
Desmarets, L.M.B., Theuns, S., Roukaerts, I.D.M., Acar, D.D., Nauwynck, H.J., 2014. Role of sialic acids in feline enteric coronavirus infections. Journal of General Virology 95(9), 1911-1918.
Dewerchin, H.L., Cornelissen, E., Nauwynck, H.J., 2005. Replication of feline coronaviruses in peripheral blood monocytes. Archives of Virology 150, 2483-2500.
Dewerchin, H.L., Cornelissen, E., Nauwynck, J.H., 2006. Feline infectious peritonitis virus–infected monocytes internalize viral membrane-bound proteins upon antibody addition. Journal of General Virology 87, 1685–1690.
Dewerchin, H.L., Cornelissen, E., van Hamme, E., 2008. Surface-expressed viral proteins in feline infectious peritonitis virus–infected monocytes are internalized through a clathrin- and caveolae-independent pathway. Journal of General Virology 89, 2731–2740.
Drechsler, Y., Alcaraz, A., Bossong, F.J., Collisson, E.W., Diniz, P.P.V.P. 2011. Feline coronavirus in multicatenvironments. Veterinary clinics of north America: small Animal Practice 41(6), 1133–1169.
Dickinson, P.J., Bannasch, M., Thomasy, S.M., Murthy, V.D., Vernau, K.M., Liepnieks, M., Montgomery, E., Knickelbein, K.E., Murphy, B., Pedersen, N.C., 2020. Antiviral treatment using the adenosine nucleoside analogue GS-441524 in cats with clinically diagnosed neurological feline infectious peritonitis. Journal of Veterinary Internal Medicine, 34(4), 587-1593.
Fehr, D., Holznagel, E., Bolla, S., Hauser, B., Herrewegh, A.A., Horzinek, M.C., Lutz, H., 1997. Placebo-controlled evaluation of a modified life virus vaccine against feline infectious peritonitis: safety and efficacy under field conditions. Vaccine 10,1101-9.
Felten, S., Hartmann, K., 2019. Diagnosis of Feline Infectious Peritonitis: A Review of the Current Literature. Viruses 11(11), 1068.
Felten, S., Hartmann, K., Doerfelt, S., Sangl, L., Hirschberger, J., Matiasek, K., 2019. Immunocytochemistry of mesenteric lymph node fine-needle aspirates in the diagnosis of feline infectious peritonitis. Journal of Veterinary Diagnostic Investigation 31(2), 210-216.
Felten, S., Matiasek, K., Gruendl, S., Sangl, L., Wess, G., Hartmann, K., 2017. Investigation into the utility of an immunocytochemical assay in body cavity effusions for diagnosis of feline infectious peritonitis. Journal of Feline Medicine and Surgery 19(4), 410-418.
Fischer, Y., Sauter-Louis, C., Hartmann, K., 2012. Diagnostic accuracy of the Rivalta test for feline infectious peritonitis. Veterinary Clinical Pathology 41, 558–567.
Fischer, Y., Weber, K., Sauter-Louis, C., Hartmann, K., 2013. The Rivalta's test as a diagnostic variable in feline effusions – evaluation of optimum reaction and storage conditions. Tierärztliche Praxis 41, 297–303.
Gerber, J.D., Ingersoll, J.D., Gast, A.M., Christianson, K.K., Selzer, N.L., Landon, R.M., Pfeiffer, N.E., Sharpee, R.L., Beckenhauer, W.H., 1990. Protection against feline infectious peritonitis by intranasal inoculation of a temperature-sensitive FIPV-vaccine. Vaccine 8(6), 536-42.
Gil, S., Leal, R.O., Duarte, A., McGahie, D., Sepúlveda, N., Siborro, I., Cravo, J., Cartaxeiro, C., Tavares, L.M., 2013. Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter. Research in Veterinary Science 94(3), 753-63.
Gordon, C.J., Tchesnokov, E.P., Feng, J.Y., Porter, D.P., Gotte, M., 2020. The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. Journal of Biological Chemistry 295(15), 4773-4779.
Gruendl, S., Matiasek, K., Matiasek, L., Fischer, A., Felten, S., Jurina, K., Hartmann, K., 2017. Diagnostic utility of cerebrospinal fluid immunocytochemistry for diagnosis of feline infectious peritonitis manifesting in the central nervous system. Journal of Feline Medicine and Surgery 19(6), 576-585.
Gunn-Moore, D.A., Gruffydd-Jones, T.J., Harbour, D.A., 1998. Detection of feline coronaviruses by culture and reverse transcriptase-polymerase chain reaction of blood samples from healthy cats and cats with clinical feline infectious peritonitis. Veterinary Microbiology 62, 193–205.
Han, S., Choi, H., Ko, M.G., 2001. Peripheral T cells become sensitive to glucocorticoid- and stress-induced apoptosis in transgenic mice overexpressing SRG3. Journal of Immunology 167(2), 805–810.
Hartmann, K., Binder, C., Hirschberger, J., Cole, D., Reinacher, M., Schroo, S., Frost, J., Egberink, H., Lutz, H., Hermanns, W., 2003. Comparison of different tests to diagnose feline infectious peritonitis. Journal of veterinary internal medicine 17(6), 781-90.
Hartmann, K., 2005. Feline infectious peritonitis. Veterinary Clinics of North America: Small Animal Practice 35(1), 39–79.
Harpold, L.M, Legendre, A.M., Kennedy, M.A., Plummer, P.J., Millsaps, K., Rohrbach, B., 1999. Fecal shedding of feline coronavirus in adult cats and kittens in an Abyssinian cattery. Journal of the American Veterinary Medical Association 215(7), 948-51.
Herrewegh, A.A., DeGroot, R.J., Cepica, A., 1995. Detection of feline coronavirus RNA in feces, tissues, and body fluids of naturally infected cats by reverse transcriptase PCR. Journal of ClinicalMicrobiology 33(3), 684–689.
Herrewegh, A.A., Smeenk, I., Horzinek, M.C., Rottier, P.J., de Groot, R.J., 1998. Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus. Journal of Virology 72(5), 4508-14.
Holzworth, J., 1963. Some important disorders of cats. The cornell veterinarian 53, 157-160.
Hohdatsu, T., Yamada, M., Tominaga, R., Makino, K., Kida, K., Koyama, H., 1998. Antibody-dependent enhancement of feline infectious peritonitis virus infection in feline alveolar macrophages and human monocyte cell line U937 by serum of cats experimentally or naturally infected with feline coronavirus. Journal of Veterinary Medical Science 60, 49–55.
Hosie, M.J., Addie, D., Belák, S., Boucraut-Baralon, C., Egberink, H., Frymus, T., Gruffydd-Jones, T., Hartmann, K., Lloret, A., Lutz, H., et al., 2009. Feline immunodeficiency. ABCD guidelines on prevention and management. Journal of Feline Medicine and Surgery 11(7), 575-84.
Howell, M., Evans, S.J.M., Cornwall, M., Santangelo, K.S., 2020. Multiplex fluorescent immunocytochemistry for the diagnosis of feline infectious peritonitis: Determining optimal storage conditions. Veterinary Clinical Pathology 49(4), 640-645.
Jeffery, U., Deitz, K., Hostetter, S., 2012. Positive predictive value of albumin:globulin ratio for feline infectious peritonitis in a mid-western referral hospital population. Journal of Feline Medicine and Surgery 14,903–905.
Jones, S., Novicoff, W., Nadeau, J., Evans, S., 2021. Unlicensed GS-441524-Like antiviral therapy can be effective for at-home treatment of feline infectious peritonitis. Animals 11, 2257.
Kennedy, M.A., Brenneman, K., Millsaps, R.K., 1998. Correlation of genomic detection of feline coronavirus with various diagnostic assays for feline infectious peritonitis. Journal of Veterinary Diagnostic Investigation 10, 93- 97.
Kennedy, M.A., 2020. Feline infectious peritonitis update on pathogenesis, diagnostics, and treatment. Veterinary Clinics of Norths America: Small Animal Practice 50(5), 1001–1011.
Klein-Richers, U., Hartmann, K., Hofmann-Lehmann, R., Unterer, S., Bergmann, M., Rieger, A., Leutenegger, C., Pantchev, N., Balzer, J., Felten, S., 2020. Prevalence of Feline Coronavirus Shedding in German Catteries and Associated Risk Factors. Viruses 12(9),1000.
Kipar, A., May, H., Menger, S., Weber, M., Leukert, W., Reinacher, M., 2005. Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis. Veterinary Pathology 42, 321-330.
Kipar, A., Baptiste, K., Barth, A., Reinacher, M., 2006. Natural FCoV infection: cats with FIP exhibit significantly higher viral loads than healthy infected cats. Journal of Feline Medicine and Surgery 8(1), 69-72.
Kipar, A., Meli, M.L., Baptiste, K.E., Bowker, L.J., Lutz, H., 2010. Sites of feline coronavirus persistence in healthy cats. Journal of General Virology 91, 1698-1707.
Kipar, A., Meli, M.L., 2014. Feline infectious peritonitis: still an enigma? Veterinary Pathology 51(2), 505-526.
Kummrow, M., Meli, M.L., Haessig, M., Goenczi, E., Poland, A., Pedersen, N, C., Hofmann-Lehmann, R., Lutz, H., 2005. Feline coronavirus serotypes 1 and 2: seroprevalence and association with disease in Switzerland. Clinical ans Diagnostic Laboratory Immunology 12(10), 1209-15.
Krentz, D., Zenger, K., Alberer, M., Felten, S., Bergmann, M., Dorsch, R., Matiasek, K., Kolberg, L., Hofmann-Lehmann, R., et al., 2021. Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524. Viruses 13(11),2228
Lai, M.M., Cavanagh, D., 1997. The molecular biology of coronaviruses. Advances in Virus Research 48, 1-100.
Lamb YN., 2020. Remdesivir: First Approval. Drugs 80(13), 1355-1363.
Lewis, K.M., O'Brien, R.T., 2010. Abdominal ultrasonographic findings associated with feline infectious peritonitis: a retrospective review of 16 cases. Journal of the American Animal Hospital Association 46(3), 152-60.
Li, X., Scott, FW., 1994. Detection of feline coronaviruses in cell cultures and in fresh and fixed feline tissues using polymerase chain reaction. Veterinary Microbiology 42(1), 65-77.
Litster, A.L., Pogranichniy, R., Lin, T.L., 2013. Diagnostic utility of a direct immunofluorescence test to detect feline coronavirus antigen in macrophages in effusive feline infectious peritonitis. Veterinary Journal 198(2), 362-6.
Lutz, H., Hauser, B., Horzinek, MC., 1986. Feline infectious peritonitis (FIP): The present state of knowledge. Journal of small animal practice 27,108–116.
Masters, P., Perlman, S., 2013. Coronaviridae. In: Knipe D, Howley P (eds). Fields virology. Philadelphia: Lippincott Williams & Wilkins, 825–858.
Meli, M.L., Burr, O., Decaro, N., 2012. Samples with high virus load cause a trend towards lower signal in feline coronavirus antibody tests. Journal of Feline Medical Surgery 15(4), 295–299.
Montali, R.J., Strandberg, J.D., 1972. Extraperitoneal Lesions in Feline Infectious Peritonitis. Veterinary Pathology 9(2), 109-121.
Morse, J.S., Lalonde, T., Xu, S., Liu, W.R., 2020. Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV. Chembiochem 21(5), 730-738.
Murphy, B.G., Perron, M., Murakami, E., Bauer, K., Park. Y., Eckstrand, C., Liepnieks, M., Pedersen, N.C., 2018. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Veterinary Microbiology 219, 226-233.
Neuman, B.W., Kiss, G., Kunding, A.H., Bhella, D., Baksh, M.F., Connelly, S., Droese, B., Klaus, J.P., Makino, S., Sawicki, S.G., et al., 2011. A structural analysis of M protein in coronavirus assembly and morphology. Journal of Structural Biology 174(1),11-22.
Oley, J.E., Pedersen, N.C., 1996. The inheritance of susceptibility to feline infectious peritonitis in purebreedcatteries. Veterinary Practice 24(1), 14–22.
Olyslaegers, D., 2014. The role of leukocyte extravasation in the pathogenesis of feline infectious peritonitis. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Olyslaegers, D.A., Dedeurwaerder, A., Desmarets, L.M., Vermeulen, B.L., Dewerchin, H.L., Nauwynck, H.J., 2013. Altered expression of adhesion molecules on peripheral blood leukocytes in feline infectious peritonitis. Veterinary Microbiology 166(3-4), 438-49.
Paltrinieri, S., Giordano, A., Stranieri, A., Lauzi, S., 2021. Feline infectious peritonitis (FIP) and coronavirus disease 19 (COVID-19): Are they similar? Transboundary and Emerging Diseases 68(4), 1786-1799.
Paltrinieri, S., Giordano, A., Tranquillo, V., Guazzetti, S., 2007. Critical assessment of the diagnostic value of feline α1-acid glycoprotein for feline infectious peritonitis using the likelihood ratios approach. Journal of Veterinary Diagnostic Investigation 19, 266–272.
Pedersen, N.C., 1976. Serologic studies of naturally occurring feline infectious peritonitis. American Journal of Veterinary Research 37(12), 1449–1453.
Pedersen, N.C., 1987. Virologic and immunologic aspects of feline infectious peritonitis virus infection. Advances in Experimental Medicine and Biology 218, 529-50.
Pedersen NC., 1995. The history and interpretation of feline corona- virus serology. Feline Practice 23:46–51.
Pederson, N.C., 2009. A review of feline infectious peritonitis virus infection. Journal of Feline Medicine and Surgery 11(4), 1963-2008.
Pedersen, N.C., 2014. An update on feline infectious peritonitis: diagnostics and therapeutics. Veterinary Journal 201(2), 133-41.
Pedersen, N.C., Black, J.W., 1983. Attempted immunization of cats against feline infectious peritonitis using either avirulent live virus or sublethal amounts of virulent virus. American Journal of Veterinary Research 44, 229–234.
Pederson, N.C., Allen, C.E., Lyons, L.A. 2008. Pathogenesis of feline enteric coronavirus infection. Journal of Feline Medicine and Surgery 10(6), 529-541.
Pedersen, N.C., Liu, H., Scarlett, J., 2012. Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats. Virus Research 165(1), 17–28.
Pedersen, N.C., Perron, M., Bannasch, M., Montgomery, E., Murakami, E., Liepnieks, M., Liu, H., 2019. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. Journal of Feline Medicine and Surgery 21(4), 271-281.
Pesteanu-Somogyi, L.D., Radzai, C., Pressler, B.M., 2006. Prevalence of feline infectious peritonitis in specific cat breeds. Journal of feline Medical Surgery 8(1), 1–5.
Poland, A.M., Vennema, H., Foley, J.E., Pedersen, N.C., 1996. Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus. Journal of Clinical Microbiology 34(12), 3180–3184.
Porter, E., Tasker, S., Day, M.J., Harley, R., Kipar, A., Siddell, S.G., Helps, C.R. 2014. Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis. Veterinary research 45, 49.
Regan, A.D., Cohen, R.D., Whittaker, G.R., 2008. Activation of p38 MAPK by feline infectious peritonitis virus regulates pro-inflammatory cytokine production in primary blood-derived feline mononuclear cells. Virology 384, 135-143.
Riemer, F., Kuehner, K.A., Ritz, S., Sauter-Louis, C., Hartmann, K., 2016. Clinical and laboratory features of cats with feline infectious peritonitis--a retrospective study of 231 confirmed cases (2000-2010). Journal of Feline Medicine and Surgery 18(4), 348-56.
Rohrbach, B.W., Legendre, A.M., Baldwin, C.A., Lein, C.A., Reed, D.H., Wilson, R.B., 2001. Epidemiology of feline infectious peritonitis among cats examined at veterinary medical teaching hospitals. Journal of the American Veterinary Medical Association 218(7), 1111–1115.
Sánchez, C.M., Izeta, A., Sánchez-Morgado, J.M., Alonso, S., Sola, I., Balasch, M., Plana-Durán, J., Enjuanes, L., 1999. Targeted recombination demonstrates that the spike gene of transmissible gastroenteritis coronavirus is a determinant of its enteric tropism and virulence. Journal of Virology 73(9), 7607-18.
Siegel, D., Hui, H.C., Doerffler, E., Clarke, M.O., Chun,K., Zhang, L., Neville, S., Carra, E., Lew, W., Ross, B., et al., 2017. Discovery and Synthesis of a PhosphoramidateProdrug of a Pyrrolo[2,1-f] [triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Journal of Medicinal Chemistry 60(5), 1648-1661.
Stout, A.E., André, N.M., Jaimes, J.A., Millet, J.K., Whittaker, G.R., 2020. Coronaviruses in cats and other companion animals: Where does SARS-CoV-2/COVID-19 fit? Veterinary Microbioly 247, 108777.
Stranieri, A., Giordano, A., Paltrinieri, S., Giudice, C., Cannito, V., Lauzi, S., 2018 Comparison of the performance of laboratory tests in the diagnosis of feline infectious peritonitis. Journal of Veterinary Diagnostic Investments 30(3), 459-463.
Stranieri, A., Scavone, D., Paltrinieri, S., Giordano, A., Bonsembiante, F., Ferro, S., Gelain, M.E., Meazzi, S., Lauzi, S., 2020. Concordance between Histology, Immunohistochemistry, and RT-PCR in the Diagnosis of Feline Infectious Peritonitis. Pathogens 9(10), 852.
Szajewska, H., Kołodziej, M., Gieruszczak-Białek, D., Skórka, A., Ruszczyński, M., Shamir, R., 2019. Systematic review with meta-analysis: Lactobacillus rhamnosus GG for treating acute gastroenteritis in children - a 2019 update. Alimentary Pharmacology & Therapeutics 49(11),1376-1384.
Tammer, R., Evensen, O., Lutz, H., Reinacher, M., 1995. Immunohisto- logical demonstration of feline infectious peritonitis virus antigen in paraffin-embedded tissues using feline ascites or murine monoclonal antibodies. Veterinary Immunology and Immunopathology 49, 177–182.
Takano, T., Ishihara, Y., Matsuoka, M., Yokota, S., Matsuoka-Kobayashi, Y., Doki, T., Hohdatsu, T., 2013. Use of recombinant nucleocapsid proteins for serological diagnosis of feline coronavirus infection by three immunochromatographic tests. Journal of Virological Methods 196, 1–6.
Takano, T., Morioka, H., Gomi, K., Tomizawa, K., Doki, T., Hohdatsu, T., 2014. Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in spike 1 domain and membrane protein of feline infectious peritonitis virus. Vaccine 32(16), 1834-40.
Takano, T., Ohyama, T., Kokumoto, A., Satoh, R., Hohdatsu, T., 2011. Vascular endothelial growth factor (VEGF), produced by feline infectious peritonitis (FIP) virus-infected monocytes and macrophages, induces vascular permeability and effusion in cats with FIP. Virus Research 158(1-2), 161-8.
Thayer, V., Gogolski, S., Felten, S., Hartmann, K., Kennedy, M., Olah, G.A., 2022 AAFP/EveryCat Feline Infectious Peritonitis Diagnosis Guidelines. Journal of Feline Medicine and Surgery 24(9), 905-933.
Taylor, S.S., Tappin, S.W., Dodkin, S.J., Papasouliotis, K., Casamian-Sorrosal, D., Tasker, S., 2010. Serum protein electrophoresis in 155 cats. Journal of Feline Medicine and Surgery 12, 643–653.
Venkatagopalan, P., Daskalova, S.M., Lopez, L.A., Dolezal, K.A., Hogue, B.G., 2015. Coronavirus envelope (E) protein remains at the site of assembly. Virology 478,75-85.
Vennema, H., Poland, A., Foley, J., Pedersen, N.C., 1998. Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. Virology 243, 150-157.
Walter, J.H., Rudolph, R., 1989. Untersuchungen zurHäufigkeit und zur Pathogenese der Felinen InfektiösenPeritonitis (FIP) [The frequency and pathogenesis of feline infectious peritonitis (FIP)]. Dtsch Tierarztl Wochenschr 96(4),194-6, 201.
Warren, T.K., Jordan, R., Lo, M.K., Ray, A.S., Mackman,R.L., Soloveva, V., Siegel, D., Perron, M., Bannister, R., Hui, H.C., et al., 2016. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 531(7594), 381-5.
Weiss, R.C., Scott, F.W., 1981. Antibody-mediated enhancement of disease in feline infectious peritonitis: Comparisons with dengue hemorrhagic fever. Comparative Immunology, Microbiology, and Infectious Disease 4, 175–189.
Yan, V.C., Muller, F.L., 2020. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. ACS Medicinal Chemistry Letters 11(7), 1361-1366.
Zhao, P., Cao, J., Zhao, L.J., Qin, Z.L., Ke, J.S., Pan, W., Ren, H., Yu, J.G., Qi, Z.T., 2005. Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine. Virology 331(1), 128-35.
